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KMID : 0606920150230040357
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Biomolecules & Therapeutics
2015 Volume.23 No. 4 p.357 ~ p.366
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Isorhamnetin Protects Human Keratinocytes against Ultraviolet B-Induced Cell Damage
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Han Xia
Piao Mei Jing
Kim Ki-Cheon
Hewage Susara Ruwan Kumara Madduma
Yoo Eun-Sook
Koh Young-Sang
Kang Hee-Kyoung
Shin Jennifer-H
Park Yeun-Soo
Yoo Suk-Jae
Chae Sung-Wook
Hyun Jin-Won
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Abstract
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Isorhamnetin (3-methylquercetin) is a flavonoid derived from the fruits of certain medicinal plants. This study investigated the photoprotective properties of isorhamnetin against cell damage and apoptosis resulting from excessive ultraviolet (UV) B exposure in human HaCaT keratinocytes. Isorhamnetin eliminated UVB-induced intracellular reactive oxygen species (ROS) and attenuated the oxidative modification of DNA, lipids, and proteins in response to UVB radiation. Moreover, isorhamnetin repressed UVB-facilitated programmed cell death in the keratinocytes, as evidenced by a reduction in apoptotic body formation, and nuclear fragmentation. Additionally, isorhamnetin suppressed the ability of UVB light to trigger mitochondrial dysfunction. Taken together, these results indicate that isorhamnetin has the potential to protect human keratinocytes against UVB-induced cell damage and death.
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KEYWORD
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Isorhamnetin, Ultraviolet B, Reactive oxygen species, Human keratinocyte, Programmed cell death
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